Madison Taylor (Merrin Dungey) is a forensic psychiatrist, spending her days interviewing prison inmates and her evenings with her husband Jeremy. When Jeremy is killed in a home invasion by Francis Tate (Devon Graye), her world begins to turn itself inside out.

A troubled federal agent with a bloody past struggles to suppress her demons while being taunted by a serial killer. A near death experience threatens to unleash her madness and put her on a collision course with her own FBI team and her nemesis. After a lifetime of being abused and left for dead, will the killer inside finally rise?

The Desmond – the building’s pleasant sounding name hides a troubled past. The high rise has a long history of fires, murders, madness and even colonial era genocide upon the site. The towering building has stood empty for the better part of a century and even squatters dare not enter it’s fortress like walls. But now Johnny Craig, the host of the popular TV paranormal investigation show ‘America’s Most Haunted’ is planning to do a prime-time special from inside The Desmond. With no known way in, or out, Craig has contacted a group of urban explorers to help him and his film crew enter the building. But when Craig and his team set foot inside The Desmond the events that caused the building to be abandoned in the first place begin to repeat.

Japanese schoolgirl Sakura (Higarino) has her idyllic small-town life turned inside-out when the local males start savagely killing the females. Armed with only her kyudo bow for protection and an English textbook for comfort, Sakura journeys through an apocalyptic world of mayhem. As trauma from witnessing the violent deaths of friends and family drives her toward madness, Sakura takes refuge in an animated dreamworld where she meets Billy (Mackenzie), a character from her English text! Billy helps her survive murderous zombies, as well as an even more formidable foe in Aoi (Tsujimoto), as she races to find real-world Billy and answers to the questions: Why is all this happening? And who or what is behind it?